New Antiviral Therapies Inspired by the Study of Naturally Occurring Compounds

Snyder, Kevin M. and Miller , Dr. Kenneth A. (2013) New Antiviral Therapies Inspired by the Study of Naturally Occurring Compounds. [Abstract]

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Abstract

Natural products are organic compounds that are produced by plants, fungi, bacteria, and animals that often are used for medicinal purposes. Sattazolin is a natural product reported to exhibit potent antiviral activity, with an ID50 of 1.5 µg/mL against herpes simplex virus type 1 (HSV1) and type 2 (HSV2). New treatments for HSV infections are critical considering that much of the world population is infected with some member of the human herpesvirus family. In particular, HSV infections can be life threatening for immunocompromised patients, pregnant women, and newborns. Acyclovir and related nucleoside analogs are currently prescribed for HSV infections, but nucleoside-resistant HSV infections have become more common. Our interest in the synthesis of sattazolin was sparked by these considerations as part of a project to determine the mechanism of action of this and other antiviral natural products and analogs. In addition, we are interested in studying the activity of these acyloins against the related herpesvirus, varicella zoster, as well as other viral strains. Described here is the first total synthesis of (+)-sattazolin, which allowed for the assignment of the previously unknown stereochemistry. More importantly, experiments to unravel the unique mechanism by which sattazolin inhibits viral growth are underway and will be described.

Item Type: Abstract
Created by Student or Faculty: Student
Additional Information: 8th Annual Natural & Behavioral Sciences Undergraduate Research Symposium Program
Uncontrolled Keywords: Natural products, Medicinal plants, Traditional medicine, Sattazolin, Antiviral agents, Herpes simplex virus type 1 (HSV1) and type 2 (HSV2), Human herpesvirus family, Immunocompromised patients, Acyclovir, nucleoside analogs, Health products, Medical care, Patients, medicinal/herbal alternatives
Subjects: School of Natural and Behavioral Sciences > Chemistry
NBS Symposium
Interdisciplinary > Pre-Health
School of Natural and Behavioral Sciences > Public Health
Depositing User: Alejandro Marquez
Date Deposited: 08 May 2013 09:54
Last Modified: 08 May 2013 09:54
URI: http://eprints.fortlewis.edu/id/eprint/259


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