Synthesis of Sattabacin, Sattazolin, and Structural Analogs and Evaluation of Antiviral Activity

Dahlke, Joshua and Regnery, Christopher and Miller , Dr. Kenneth A. (2012) Synthesis of Sattabacin, Sattazolin, and Structural Analogs and Evaluation of Antiviral Activity. [Abstract]

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Abstract

Progress toward convergent syntheses of the antiviral natural products sattabacin and sattazolin that allow for structural variation is presented. Synthetic strategies for the systematic variation of aromatic substitution have been developed and will be discussed. Building on our previous asymmetric synthesis of (+)-sattabacin, the straightforward preparation of a number of side chain analogs was also completed. Evaluation of the antiviral activity of the natural products and analogs against Varicella zoster virus are underway, and this progress will also be included.

Item Type: Abstract
Created by Student or Faculty: Student
Additional Information: 7th Annual Natural & Behavioral Sciences Undergraduate Research Symposium Program
Uncontrolled Keywords: Antiviral, Natural products, Sattabacin, Sattazolin, Aromatic substitution, Varicella zoster virus, Structural analogs, Antiviral activity
Subjects: School of Natural and Behavioral Sciences > Chemistry
NBS Symposium
Depositing User: Alejandro Marquez
Date Deposited: 26 Jun 2013 14:13
Last Modified: 26 Jun 2013 14:13
URI: http://eprints.fortlewis.edu/id/eprint/281


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