Asymmetric Total Synthesis of the Antiviral Natural Products Sattabacin, 4-hydroxysattabacin and Sattazolin

Heins, Spencer and Aronoff, Matthew (2011) Asymmetric Total Synthesis of the Antiviral Natural Products Sattabacin, 4-hydroxysattabacin and Sattazolin. [Abstract]

Full text not available from this repository.

Abstract

The first asymmetric total syntheses of the antiviral natural products (+)-sattabacin and (+)-4-hydroxysattabacin are reported. Progress toward the asymmetric total synthesis of (+)-sattazolin is also reported. These total syntheses are remarkably concise and were completed without the use of protecting groups. Unambiguous assignment of the absolute configuration of both (+)-sattabacin and (+)-4-hydroxysattabacin was also accomplished. The syntheses of these natural products, which exhibit potent antiviral activity, are readily amenable to the preparation of structural analogs and progress in this regard is also presented.

Item Type: Abstract
Created by Student or Faculty: Student
Additional Information: 6th Annual Natural & Behavioral Sciences Undergraduate Research Symposium Program
Uncontrolled Keywords: Asymmetric Total Synthesis, Antiviral Natural Products, Sattabacin, 4-hydroxysattabacin, Sattazolin, Antiviral, Structural analogs and progress
Subjects: School of Natural and Behavioral Sciences > Chemistry
NBS Symposium
Interdisciplinary > Pre-Health
School of Natural and Behavioral Sciences > Public Health
Depositing User: Alejandro Marquez
Date Deposited: 22 May 2013 13:13
Last Modified: 22 May 2013 13:13
URI: http://eprints.fortlewis.edu/id/eprint/345


© FortWorks - powered by EPrints 3 - sponsored and maintained by the John F. Reed Library at Fort Lewis College