Synthesis and Characterization of Cobalt(III) Complexes with Nitrogen-Containing Heterocyclic Ligands as Possible Anti-Cancer Pro-Drugs

Garcia, Mario and Hart, Kaila F. and Joe, Natalie and Nopah, Matthew and Padilla, Thomas and Morris, Aimee M. Synthesis and Characterization of Cobalt(III) Complexes with Nitrogen-Containing Heterocyclic Ligands as Possible Anti-Cancer Pro-Drugs. In: Undergraduate Research and Creative Activities Symposium, 2014. (Unpublished)

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    Abstract

    Research into better cancer treatments has been a progressively growing field. Metal containing coordination compounds offer unique chemistry that could prove useful. A ruthenium(III) compound with two indazole and four chlorine ligands, KP1019, is currently in phase III clinical trials as a pro-drug for the treatment of cancer. Our research delved into creating similar compounds to KP1019 but with cobalt centers instead of ruthenium, and with various nitrogen-containing heterocyclic ligands. Starting with cobalt(II) chloride and ligands including: imidazole, pyrimidine, indazole, pyridine, pyrazole, L-histidine or L-tryptophan, we attempted to oxidized the metal center and attach the desired ligands. Each ligand presented its own unique aspects and binding properties. A 4:1 metal to ligand ratio was most commonly used, however this ratio was altered based on the denticity of the specific ligand and our desired binding sites.

    Item Type: Conference or Workshop Item (Poster)
    Created by Student or Faculty: Student
    Subjects: Undergrad Research Symposium > Chemistry
    Undergrad Research Symposium
    Depositing User: Aimee Morris
    Date Deposited: 16 Apr 2014 14:55
    Last Modified: 18 Apr 2014 10:37
    URI: http://fortworks.fortlewis.edu/id/eprint/499


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