Preparation Of Drugs To Selectively Kill Cancer Cells

Reese, Caitlyn and Askeland, Gracie and Caldera, Hector and Chavez, Marlyn and Baldwin, Raina and Miller, Kenneth A. (2014) Preparation Of Drugs To Selectively Kill Cancer Cells. [Abstract]

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Rottlerin is a natural product isolated from the fruit of the kamala tree. Previous studies have shown that it is a potent inhibitor of protein kinase C delta, an enzyme that is critical for the survival of many types of cancer cells. However, treatment of non-cancerous cells with similar doses of rottlerin has no effect. Thus rottlerin, or compounds similar in structure, could find use as selective drugs to kill cancer cells without harming healthy cells. The goal of this project was to synthesize a palladium catalyst that could be used in future experiments to synthesize rottlerin analogs.

Item Type: Abstract
Created by Student or Faculty: Student
Uncontrolled Keywords: cancer, rottlerin, PKC delta inhibitors
Subjects: Undergrad Research Symposium > Chemistry
Undergrad Research Symposium
Depositing User: Caitlyn Reese
Date Deposited: 16 Apr 2014 15:41
Last Modified: 25 Apr 2014 09:33

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