Synthesis of Conformationally Constrained Diarylether Paracyclophanes

Caldera, Hector and Tregillus, Zoe and Ozvat, Tyler and Cooper-Sansonne, Andrew (2016) Synthesis of Conformationally Constrained Diarylether Paracyclophanes. [Abstract]

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The syntheses of a series of macrocyclic diarylether paracyclophanes with varying length in the bridging chain are reported. Several naturally occurring biologically active cyclophanes have been described in the literature, and many of these are chiral by virtue of restricted bond rotation opposed to the presence of stereocenters. We report the first systematic study of the relationship between the bridging chain length and the barrier to racemization of these important compounds. Progress toward the synthesis of a library of diarylether paracyclophanes with varying tether lengths is described, as well as stereochemical implications.

Item Type: Abstract
Created by Student or Faculty: Faculty
Subjects: Undergrad Research Symposium > Chemistry
Undergrad Research Symposium
Depositing User: Kenny Miller
Date Deposited: 11 Apr 2016 16:19
Last Modified: 11 Apr 2016 16:19

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