Synthesis of Haploscleridamine and Biologically Significant Analogs

Wegener, Aaron and Absher, Nathan and Metze, Bryan and Harrison, Jacob A. and Rodriguez, Lydia and Chadeayne, Devon (2016) Synthesis of Haploscleridamine and Biologically Significant Analogs. [Abstract]

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Haploscleridamine, a molecule isolated from a sponge of the order Haplosclerida, is a member of a group of natural products that selectively inhibits the E1 ubiquitin pathway and thus shows promise as an anti-cancer drug. We report the development of a reliable synthetic route to Haploscleridamine.

Item Type: Abstract
Created by Student or Faculty: Faculty
Subjects: Undergrad Research Symposium > Chemistry
Undergrad Research Symposium
Depositing User: Kenny Miller
Date Deposited: 11 Apr 2016 16:26
Last Modified: 11 Apr 2016 16:26

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