Natural Product Synthesis of Diarylether Cyclophanes

Ozvat, Tyler (2016) Natural Product Synthesis of Diarylether Cyclophanes. [Abstract]

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Abstract

Diarylether heptanoids are naturally occurring cyclophane compounds that exhibit a wide range of biological activities such as anti-cancer, anti-viral, anti-inflammatory, and antioxidant properties. The biological activities of these cyclophanes can be attributed to the strained seven-carbon tether which is largely responsible for the chirality of these macrocyclic structures. We report work towards developing synthetic strategies for a series of diarylether cyclophanes with varying degrees of conformational strain to investigate the relationship between structural integrity, barrier to racemizatoin, and biological activity. The synthesis and characterization of both seven and eight-carbon tether cyclophanes were successful where the eight-carbon tether cyclophane is the first ever reported.

Item Type: Abstract
Created by Student or Faculty: Faculty
Subjects: Undergrad Research Symposium > Chemistry
Undergrad Research Symposium
Depositing User: Kenny Miller
Date Deposited: 12 Apr 2016 11:52
Last Modified: 12 Apr 2016 11:52
URI: http://fortworks.fortlewis.edu/id/eprint/789


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